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情報全件数:262件
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抗Pura抗体、ウサギポリクロ
2015年11月04日 15時58分28秒

商品コード:70-460

This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. Human and mouse Pura has molecular mass of 35 kDa.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=70-460

抗Med9/Cse2 (S. cerevisiae)抗体、ウサギPC抗血清
2015年11月04日 15時57分54秒

商品コード:62-029

Med9 is a component of the Mediator complex a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex having a compact conformation in its free form is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins
Med9 consists of 149 amino acids with molecular mass of 17376 Da
http://www.bioacademia.co.jp/product_list.php?srch_keyword=62-029

抗Ada3/Ngg1 (S. cerevisiae)抗体、ウサギPC抗血清
2015年11月04日 15時57分23秒

商品コード:62-028

Ngg1 transcription regulator. Could inhibit GAL4 DNA-binding or its ability to activate transcription. Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA SALSA SLIK and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3 SPT8 and SPT20) and promoter selectivity interaction with transcription activators (GCN5 ADA2 ADA3 and TRA1) and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac H3K14ac H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA an altered form of SAGA may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3 at least after activation at the GAL1-10 locus. ADA preferentially acetylates nucleosomal histones H3 (at Lys-14 and Lys-18) and H2B.
NGG1 consists of 702 amino acids with molecular mass of 79282 Da
http://www.bioacademia.co.jp/product_list.php?srch_keyword=62-028

抗Ada2 (S. cerevisiae)抗体、ウサギPC抗血清
2015年11月04日 15時56分57秒

商品コード:62-027

Ada2 functions as component of the transcription regulatory histoneacetylation (HAT) complexes SAGA SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3 SPT8 and SPT20) and promoter selectivity interaction with transcription activators (GCN5 ADA2 ADA3 and TRA1) and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac H3K14ac H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA an altered form of SAGA may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3 at least after activation at the GAL1-10 locus. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B
Ada2 consists of 434 amino acids with molecular mass of 50569 Da
http://www.bioacademia.co.jp/product_list.php?srch_keyword=62-027

抗Tfa1/TFIIEa (S. cerevisiae)抗体、ウサギPC抗血清
2015年11月04日 15時56分38秒

商品コード:62-026

Tfa1 recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase
Taf14 consists of 482 amino acids with molecular mass of 54742 Da
http://www.bioacademia.co.jp/product_list.php?srch_keyword=62-026

抗Taf14 (S. cerevisiae)抗体、ウサギPC抗血清
2015年11月04日 15時56分12秒
商品コード:62-025

Taf14 functions as a component of the DNA-binding general transcription factor complex TFIID the RNA polymerase II associated general transcription factor complex TFIIF and the chromatin-remodeling complex SWI/SNF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction core promoter recognition and selectivity TFIIA and TFIIB interaction chromatin modification (histone acetylation by TAF1) facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex decreasing the affinity of RNA polymerase II for non-specific DNA allowing for the subsequent recruitment of TFIIE and TFIIH and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex an ATP-dependent chromatin-remodeling complex is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome leading eventually to a change in nucleosome position thus facilitating or repressing binding of gene-specific transcription factors. Component of the histone acetyltransferase NuA3 complex that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex NuA3 may be involved in transcriptional regulation.
Taf14 consists of 244 amino acids with molecular mass of 27440 Da .
http://www.bioacademia.co.jp/product_list.php?srch_keyword=62-025

抗Taf7 (S. cerevisiae)抗体、ウサギPC抗血清
2015年11月04日 15時55分43秒

商品コード:62-024

Taf3 functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction core promoter recognition and selectivity TFIIA and TFIIB interaction chromatin modification (histone acetylation by TAF1) facilitation of DNA opening and initiation of transcription. TAF7 is responsible for the recruitment of BDF1 to TATA element containing promoters
http://www.bioacademia.co.jp/product_list.php?srch_keyword=62-024

抗Taf3 (S. cerevisiae)抗体、ウサギPC抗血清
2015年11月04日 15時55分22秒
商品コード:62-023

Taf3 functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction core promoter recognition and selectivity TFIIA and TFIIB interaction chromatin modification (histone acetylation by TAF1) facilitation of DNA opening and initiation of transcription.

Taf3 consists of 353 amino acids with molecular mass of 40296 Da.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=62-023

抗βガラクトシダーゼ抗体、ウサギポリクロ血清
2015年11月04日 15時54分40秒

商品コード:60-060
β-galactosidase is an exoglycosidase which hydrolyzes the β-glycosidic bond formed between agalactose and its organic moiety. It may also cleave fucosides and arabinosides but with much lower efficiency. It is an essential enzyme in the human body. Deficiencies in the protein can result ingalactosialidosis or Morquio B syndrome. In E. coli the gene of β-galactosidase the lacZ gene is present as part of the inducible system lac operon which is activated in the presence of lactose when glucose level is low.
It is commonly used in molecular biology as a reporter marker to monitor gene expression. It also exhibits a phenomenon called α-complementation which forms the basis for the blue/white screening of recombinant clones. This enzyme can be split in two peptides LacZα and LacZΩ neither of which is active by itself but when both are present together spontaneously reassemble into a functional enzyme. This property is exploited in many cloning vectors where the presence of the lacZα gene in a plasmid can complement in trans another mutant gene encoding the LacZΩ in specific laboratory strains of E. coli. However when DNA fragments are inserted in the vector the production of LacZα is disrupted the cells therefore show no β-galactosidase activity. The presence or absence of an active β-galactosidase may be detected by X-gal which produces a characteristic blue dye when cleaved by β-galactosidase thereby providing an easy means of distinguishing the presence or absence of cloned product in a plasmid.
E. coli β-Galactosidase consists of 1024 amino acids with molecular mass of 116 kDa and functional form is a homotetramer.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=60-060

HIV-1プロテアーゼ
2015年11月04日 15時54分01秒
商品コード:05-013

HIV-1 protease is the aspartyl protease that mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell. Also cleaves Nef and Vif probably concomitantly with viral structural proteins on maturation of virus particles. Hydrolyzes host EIF4GI and PABP1 in order to shut off the capped cellular mRNA translation. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=05-013

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