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情報全件数:272件
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抗Varicella Zoster Virus (VZV) gH抗体、マウスモノクロナル(OAKK39)
2015年11月04日 16時04分24秒
商品コード:65-363

Varicella Zoster Virus (VZV) is one of eight herpesviruses known to infect humans and vertebrates. VZV only affects humans and commonly causes chickenpox in children teens and young adults and herpes zoster (shingles) in adults and rarely in children. VZV is known by many names including chickenpox virus varicella virus zoster virus and human herpesvirus type 3 (HHV-3).
VZV infects the nerves and causes a wide variety of symptoms. After the primary infection (chickenpox) the virus goes dormant in the nerves including the cranial nerve ganglia dorsal root ganglia and autonomic ganglia. Many years after the patient has recovered from chickenpox VZV can reactivate to cause a number of neurologic conditions
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis
gH is consists of 841 amino acids with molecular mass of 94 kDa
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抗Varicella Zoster Virus (VZV) gE抗体、マウスモノクロナル(#9)
2015年11月04日 16時03分54秒
商品コード:65-358

Varicella Zoster Virus (VZV) is one of eight herpesviruses known to infect humans and vertebrates. VZV only affects humans and commonly causes chickenpox in children teens and young adults and herpes zoster (shingles) in adults and rarely in children. VZV is known by many names including chickenpox virus varicella virus zoster virus and human herpesvirus type 3 (HHV-3).
VZV infects the nerves and causes a wide variety of symptoms. After the primary infection (chickenpox) the virus goes dormant in the nerves including the cranial nerve ganglia dorsal root ganglia and autonomic ganglia. Many years after the patient has recovered from chickenpox VZV can reactivate to cause a number of neurologic conditions
gE is envelope glycoprotein that binds to the potential host cell entry receptor IDE.
In epithelial cells the heterodimer gE/gI is required for the cell-to-cell spread of the virus by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9 the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.
The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-VZV antibodies bipolar bridging followed by intracellular endocytosis and degradation thereby interfering with host IgG-mediated immune responses .
gE consists of 623 amino acids with 70 kDa mass. It is phosphorylated on serines within the acidic cluster. Phosphorylation determines whether endocytosed viral gE traffics to the trans-Golgi network or recycles to the cell membrane.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=65-358

抗Varicella Zoster Virus (VZV) IE62抗体、マウスモノクロナル(62B)
2015年11月04日 16時03分08秒
商品コード:65-353

Varicella Zoster Virus (VZV) is one of eight herpesviruses known to infect humans and vertebrates. VZV only affects humans and commonly causes chickenpox in children teens and young adults and herpes zoster (shingles) in adults and rarely in children. VZV is known by many names including chickenpox virus varicella virus zoster virus and human herpesvirus type 3 (HHV-3).
VZV infects the nerves and causes a wide variety of symptoms. After the primary infection (chickenpox) the virus goes dormant in the nerves including the cranial nerve ganglia dorsal root ganglia and autonomic ganglia. Many years after the patient has recovered from chickenpox VZV can reactivate to cause a number of neurologic conditions
Immediate early protein 62 (IE62) of is major transcriptional transactivator of VZV. It may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. It interacts with IE4 and IE63 and with host USF and Sp1.It negatively regulates its own transcription. This immediate early protein may be necessary in virion for viral pathogenesis.
IE62 consists of 1310 amino acids with 140 kDa mass. It is phosphorylated by ORF66 protein kinase on Ser-686 and Ser-722. It is also phosphorylated by ORF47 protein kinase and human CSNK2A1/CKII.SK
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抗Varicella Zoster Virus (VZV) IE62抗体、マウスモノクロ(62A)
2015年11月04日 16時02分24秒

商品コード:65-350

Varicella Zoster Virus (VZV) is one of eight herpesviruses known to infect humans and vertebrates. VZV only affects humans and commonly causes chickenpox in children teens and young adults and herpes zoster (shingles) in adults and rarely in children. VZV is known by many names including chickenpox virus varicella virus zoster virus and human herpesvirus type 3 (HHV-3).
VZV infects the nerves and causes a wide variety of symptoms. After the primary infection (chickenpox) the virus goes dormant in the nerves including the cranial nerve ganglia dorsal root ganglia and autonomic ganglia. Many years after the patient has recovered from chickenpox VZV can reactivate to cause a number of neurologic conditions
Immediate early protein 62 (IE62) of is major transcriptional transactivator of VZV. It may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. It interacts with IE4 and IE63 and with host USF and Sp1.It negatively regulates its own transcription. This immediate early protein may be necessary in virion for viral pathogenesis.
IE62 consists of 1310 amino acids with 140 kDa mass. It is phosphorylated by ORF66 protein kinase on Ser-686 and Ser-722. It is also phosphorylated by ORF47 protein kinase and human CSNK2A1/CKII.SK
http://www.bioacademia.co.jp/product_list.php?srch_keyword=65-350

抗HIV-1プロテアーゼ抗体、ウサギポリクロ
2015年11月04日 16時01分42秒

商品コード:65-018

HIV-1 protease is the aspartyl protease that mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell. Also cleaves Nef and Vif probably concomitantly with viral structural proteins on maturation of virus particles. Hydrolyzes host EIF4GI and PABP1 in order to shut off the capped cellular mRNA translation. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=65-018

抗SLC2A3 / GLUT3 抗体 ラットモノクロ(#10)
2015年11月04日 16時01分07秒
商品コード:74-200

53479 with 493 amino acids.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=74-200

抗ADAM1B抗体、ラットモノクロ(#158)
2015年11月04日 16時00分33秒

商品コード:73-007

89369 with 806 amino acids. N-terminal signal peptide with 33 amino acids from this protein is processed to give propeptide which may undergo further processing. By western blotting ADAM1B is detected in testis extract at 120 kDa position and in sperm extract at 60 kDa (Ref. 1 & 2) .
http://www.bioacademia.co.jp/product_list.php?srch_keyword=73-007

抗PIAS4/PIASy 抗体 マウスモノクロ (10-24.6)
2015年11月04日 16時00分03秒

商品コード:70-510

PIAS4 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase stabilizing the interaction between UBE2I and the substrate and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways including the STAT pathway the p53/TP53 pathway the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA PARK7 HERC2 MYB TCF4 and RNF168. In Wnt signaling represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.Human
PIAS4 consists of 510 amino acids with molecular mass of 56504 Da.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=70-510

抗GAK 抗体、マウスモノクロ (9-10)
2015年11月04日 15時59分25秒
商品コード:71-203

Cyclin-G-associated kinase) a serine/threonine kinase that functions in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Its non-kinase domain is homologous to auxilin that is mainly expressed in neuronal cells. Human GAK consists of 1311 amino acids with molecular mass of 143 kDa.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=71-203

抗GAK 抗体、マウスモノクロ (9-13)
2015年11月04日 15時59分00秒

商品コード:71-200

(Cyclin-G-associated Kinase) a serine/threonine kinase that functions in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Its non-kinase domain is homologous to auxilin that is mainly expressed in neuronal cells. Human GAK consists of 1311 amino acids with molecular mass of 143 kDa.
http://www.bioacademia.co.jp/product_list.php?srch_keyword=71-200

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