汎用品年度末キャンペーン実施中 ~ 2018年3月31日まで
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商品コード: 64-022

Background: Pathogenic Escherichia coli is one of the major causative agents of food poisoning. One group of them, enterotoxigenic E. coli (ETEC) produces some toxins. Heat labile enterotoxin (LT) produced by ETEC is similar to cholera toxin (CT). The identity of the amino acid sequences of LT and CT is about 80% and both toxins are consist of one subunit A and five subunit B. LT continuously activates adenylate cyclase and elevated level of cAMP inhibits absorption of Na+ by intestinal villi cells, and stimulates secretion of Cl- by villi and crypt cells, thus causing diarrhea. Subunit A possesses signal peptide of the amino acids 1-18, and the mature form consists of 19-258 amino acids (MW: 28.8 kDa). Subunit B has signal peptide of 1-21, and the mature form consists of 22-124 amino acids (MW: 11.8 kDa). The holotoxin MW is 86.4 KDa.
 
 
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64-022
100 ug
39,000円(税抜)

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